Metabolomics

Mathomics provides the following services for storage and analysis of metabolomic data:

Storage

Our current storage capacity is around 10 TB but it can be expanded depending on client requirements.

Data Analysis

We use the MeltDB platform (developed by University of Bielefeld), XCMS software (developed by the Scripps Center for Metabolomics and Mass Spectrometry) and in-house developed tools to provide the following analysis:

  • Data filtration
  • Automatic peak detection
  • Automatic standard compound annotation
  • Putative peak annotation based on database searches
  • Putative Adduct and Isotope annotation
  • Chromatograms alignment
  • Statistical analysis of multiple samples  (Hierarchical Clustering, PCA analysis, CART, etc.)
  • Integration of genomic and metabolomic data
  • Data Access and Visualization
  • Restricted access to data : The client can have access to his/her data through the web interface of the MeltDB platform using a username and password.
  • Visualization: The MeltDB platform allows the user to browse his/her data and the results of the analysis described above in a user friendly web interface. 
  • MeltDB platform installed locally allowing in-house customization according to clients requirements.   

Sample processing can be executed by the CMPB (Laboratory Equipment : A S1200 LC for liquid chromatography and a Q-TOF 6520 spectrometer (Agilent Technologies)).

Example: Mathomics and BioSigma performed the first metabolome study on biomining bacterias: Acidithiobacillus ferrooxidans (Wenelen) and Acidithiobacillus thiooxidans (Licanantay) performed over an CE/MS platform, jointly with the Institute of Advanced BioSciences (IAB, Japan). Based on this experience, both groups formed the Center of Metabolomics and Proteomics (CMPB, INNOVA-Chile Project 09CN14-5855), to provide metabolomics services to the scientific community.